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Marsh Stage of Celiac Disease


Updated October 07, 2009

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Marsh Score for Celiac Disease, Stage 0
Marsh Stage of Celiac Disease

From Ludvigsson et al. BMC Gastroenterology 2009 9:19.

© 2009 Ludvigsson et al.
This is a photomicrograph of a biopsy sample of the lining of a normal small intestine. The villi and crypts are undamaged. When the tissue sample looks like this, celiac disease is very unlikely. This biopsy sample would be Stage 0, also known as the "pre-infiltrative stage," because lymphocytes have not yet started to infiltrate the epithelium.


This photomicrograph is from Figure 1a of Ludvigsson et al. BMC Gastroenterology 2009 9:19. doi:10.1186/1471-230X-9-19. The photomicrographs were obtained from Prof. Åke Öst, earlier chairman of the Swedish National Steering Group for Small Intestinal Pathology.


Ludvigsson JF, Brandt L, Montgomery SM, Granath F, Ekbom A. Validation study of villous atrophy and small intestinal inflammation in Swedish biopsy registers. BMC Gastroenterol. 2009;9:19.

Snyder CL, Young DO, Green PHR, Taylor AK. GeneReviews: Celiac Disease. 2009

Hill ID, Dirks MH, Liptak GS, et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society fo Pediatric Gastroenterology, Hepatology and Nutrition. Journal of Pediatric Gastroenterology and Nutrition 2005;40:1-19.

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